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Chromosome 18p deletion is a chromosome abnormality that occurs when there is a missing copy of genetic material on the short arm (p) of chromosome 18.The severity of the condition and the signs and symptoms depend on the size and location of the deletion and which genes are involved. Infants, toddlers and young children with proximal 18q- may develop more slowly than those without proximal 18q-. She can sign (language) a little, and just learned to kind of crawl. In people with distal 18q deletion syndrome, myelination is often delayed and proceeds more slowly than normal; affected individuals may never have normal adult myelin levels. Does this mean she will always have developmental disorders even if she's on growth hormones? Will she always be behind in her capabilities? Features that often occur in people with chromosome 18p deletion include developmental … Proximal 18q- changes the way the brain develops and works. My friend's daughter has this, she is over 2 years of age and still is unable to talk or walk. These problems include delayed development, learning … 18q minus syndrome? Most people with distal 18q deletion syndrome have neurological problems, although it is unclear to what extent these problems are related to the dysmyelination. For example, it may take a little longer for them to roll over, sit, crawl, and walk.