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Dit gen is betrokken bij de motoriek van de mond en tong en we weten dat ADHD en spraak-taalstoornissen regelmatig samen optreden, maar er is meer onderzoek nodig om die link goed te begrijpen.” “Dit onderzoek legt een belangrijk fundament voor verder onderzoek naar ADHD…

Large genetic study finds first genes connected with ADHD There's overlap with risk for a range of other conditions and behaviors. Gene variants predicting risk for ADHD are important for brain development, cell migration, and encoding for catecholamine receptor and transporter genes . Satterstrom and his colleagues are creating a list of genes mutated in the combined group of all people with autism, ADHD or both.
The report was published online Nov. 26 in the journal Nature Genetics. None of the genes affected by the drugs showed up in their analysis of genes tied to ADHD, Faraone said. Genetic mutations on specific genes — known as glutamate receptor metabotropic (GRM) network genes — may play an important role in ADHD diagnoses, a new study finds. Their goal is to identify risk genes associated with both conditions.

Loci are stretches of thousands of DNA letters, most of which contain many genes, as well as other areas where DNA regulates the activity of nearby genes. … So far, the top gene, called MAP1A, is mutated in 11 people with either or both conditions and none of the controls. Further common genes were isolated for multiple disorders. While there is general agreement about genetic contributions toward the disorder, progress in leveraging genetics to learn more about the biology and risk factors for ADHD has been limited. Actually the list of gene candidates is over 100.

Thus, finding “loci” is only the beginning of the discovery process.

The 12 reported loci are the first genomic “risk” sites for ADHD that survive mathematical tests of robustness.

More information: Jordi Corominas et al, Identification of ADHD risk genes in extended pedigrees by combining linkage analysis and whole-exome sequencing, Molecular Psychiatry (2018). More than 20 genes have been associated with ADHD.
A list of common genes can be seen in the Table.2.

But, unlike some illnesses, which are determined by a single gene, ADHD is not easily pinned down. The study examined more than 1,000 children from across the United States; all were between the ages of 6 and 17, and all had documented ADHD diagnoses or symptoms.

The children underwent genotyping using saliva samples. Fisher et al. Cathleen O'Grady - Nov 27, 2018 9:46 pm UTC For ADHD, 67 genes were reported, 39 for ID, 86 for ASD and out 242 only top 100 closely related genes were taken for SZ (Table.1). Researchers have been unable to identify a single cause for ADHD. (2002) performed the first systematic genomewide linkage scan for loci affecting ADHD in 126 affected sib pairs (ASPs).