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B cell development is a highly regulated process whereby functional peripheral subsets are produced from hematopoietic stem cells, in the fetal liver before birth and in the bone marrow afterward. CD3, a T cell specific marker, is necessary to differentiate T cells from other populations, simply because CD4 and CD8 can be expressed by other cell types. Overview of B cell development • Early B cell development constitutes the steps that lead to B cell commitment and expression of surface immunoglobulin, production of mature B cells • Mature B cells leave the bone marrow and migrate to secondary lymphoid tissues • B cells then interact with exogenous antigen and/or T helper cells = antigen- Learn the basic principles of development. Title: T cell development 1 T cell development.
T cells are derived from haematopoietic stem cells that are found in the bone marrow. Consider implications for vaccine production CTLA-4-Ig can inhibit immune responses (consider mechanism and potential uses). T cells populate virtually every organ and tissue, including primary and secondary lymphoid tissue, mucosal and barrier sites, exocrine organs, fat, and even the brain and central nervous system. T Cell Development Author: UVM Affilaite Last modified by: Lisa-Marie McKenzie Created Date: 3/8/2005 6:35:04 PM Document presentation format: On-screen Show Other titles: Arial Verdana Times New Roman Wingdings Profile Principles of Immunology B Cell Development 3/16/06 Word/Terms List B Cell Development Lymphopoiesis B Cell Maturation Slide 6 Slide 7 B Cell Changes Slide 9 B Cell … ... MHC molecules bind and transport antigen fragments to the cell surface, a process called antigen presentation. • Interaction of CTLA-4 with B7 is thought to down- regulate T cell activation. Initially the fetal liver followed by hematopoietic stem cell progenitors (HSC) in the bone marrow gives rise to lymphocytes and polymorphonuclear cells - neutrophils, eosinophils and mast cells. 2) gel electrophoresis of. Anti-CTLA-4-antibody can contribute to a more vigorous immune Winner of the Standing Ovation Award for “Best PowerPoint Templates” from Presentations Magazine. Generation of T Cells. Introduction. Clinical Diagnosis. Self tolerance T cells cannot recognize self What are the 2 phases of. Thymus: the Site of T-Cell Development. Download (PPT) The role of T cells in immune responses and at different life stages is not uniform across the body. T cell development occurs in the thymus; the thymic microenvironment directs differentiation as well as positive and negative selection. Penny Morel ; 2/26/07 ; 4-0343, morel_at_pitt.edu; 2 Two fundamental features characterize mature T cell antigen recognition. • There are actually two related molecules: B7.1 and B7.2 Expressed after T cell The developing progenitors within the thymus, also known as thymocytes, undergo a series of maturation steps that can be identified based on the expression of different cell surface markers. The PBMC cell type I have the most experience with characterizing is T cells. Pre-T-cells can express only the β-chain of TCR, but when this Pre-T-cell differentiates into a double positive T-cell , it can express on its surface both the α- and β-chains.